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Investigating the association between GLP-1 receptor agonists and mood disorders: A study integrating real-world data and Mendelian randomization Published online by Cambridge University Press: 03 December 2025 Abstract As GLP-1 receptor agonists (GLP-1 RAs) are increasingly used worldwide, concerns about their association with mood disorders have grown
Clinical research, including randomized withdrawal studies of the semaglutide group, shows that individuals who continue treatment while maintaining healthy habits are more likely to sustain their weight loss
Acetyl-L-carnitine for symptomatic diabetic neuropathy [letter]
Week 21 and beyond: 15 mg once weekly
An 8-week treadmill exercise at 70%85% VO 2 max significantly downregulated the levels of TFR1, TF, DMT1, FTL, FTH, mitochondrial Ferritin, -secretase, and APP in the cortical motor regions of aged amyloid precursor protein-C105 (APP-C105) mice, upregulated the expression of FPN1, Furin, and -secretase, significantly reduced Fe 2+ , Fe 3+ , and total iron content, inhibited brain iron accumulation and A plaque growth, thereby improving learning ability, memory, and cognitive function in aged APP-C105 mice (Choi et al., 2021)
