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Vivancos et al., 2010)

KLOW is not appropriate for patients who are pregnant or breastfeeding, have active cancer or a recent cancer history, or are on immunosuppressive therapy

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11 Another study, by Simone et al., found that intradermal injections of capsaicin in humans resulted in primary hyperalgesia to heat and mechanical stimuli

[10] Additive depressant effects occur with other class I antiarrhythmics, phenytoin, and volatile anesthetics, while epinephrine-containing local formulations may potentiate vasoconstriction and delay systemic absorption-beneficial for prolonging local anesthesia but hazardous if inadvertent intravascular injection occurs