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10.1111/j.1365-2249.2011.04552.x 18 GuiradoE.SchlesingerL

To further investigate the role of lipid catabolism in fasting-induced longevity, we examined two key regulators: Adipose Triglyceride Lipase-1 (ATGL-1), which initiates lipolysis, and Carnitine Palmitoyl Transferase-2 (CPT-2), which catalyzes carnitine removal and Coenzyme A conjugation to the fatty acid within the mitochondrial matrix 43,44

Homocysteine-mediates redox imbalance and increases expression of cell adhesion molecules to accelerate monocyte recruitment Koga et al., 2002 showed that homocysteine boosts expression of adhesion molecules to enhance endothelial cell interactions with T cells and monocytes, hence promoting the development of atherosclerosis

Additionally, the study indicated a potential decrease in the expression of urea cycle enzymes in animal models

The difference was meaningful in research terms but small in absolute terms, which is why responsible framing presents AOD 9604 as a possible adjunct to diet and training, not a replacement for them