The findings of the rapid and long-lasting antidepressant effects of LAC (which increases the expression of mGlu2, inhibitor of spontaneous glutamate release) supports the idea that targeting the glutamate system can lead to rapid antidepressant effects in agreement with the prior discovery of the antidepressant action of ketamine [48,49,50]
Vitamin C injections involve the parenteral administration of ascorbic acid through intravenous (IV), intramuscular (IM), or subcutaneous (SC) routes
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638 Saikosaponin B2 alleviates ER stress by regulating intracellular Ca 2+ levels, reducing lipid peroxidation and intracellular Fe 2+ content, and inhibiting ferroptosis in a GPX4-dependent manner, thereby improving CUMS-induced depressive behavior