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73 It has been shown that the changes in gut microbiome and concentrations of the aforementioned metabolites is important in NAFLD pathogenesis and progression, but a specific microbiome composition in NAFLD has not yet been identified

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Front Immunol 12:1 DiSabato DJ, Quan N, Godbout JP (2016) Neuroinflammation: the devil is in the details

The lack of anti-atherosclerotic and plaque-stabilizing effects of incretin-based medications might contribute to elevated cardiovascular risk, especially acutely following their discontinuation

Manual validation ensured accurate identification of all amino acid residues and post-translational modifications. Nuclear Magnetic Resonance (NMR) Spectroscopy To complement mass spectrometric data, ^1H and ^13C NMR spectroscopy were performed, providing insights into the conformational aspects and confirming the presence of specific functional groups, particularly in modified regions. Quality Control and Batch-to-Batch Comparability Assessment (New Section) Beyond single-batch characterization, peptide sequencing plays a vital role in establishing batch-to-batch consistency during late-stage development