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Such disruptions have been associated with worsened DED symptoms, decreased corneal barrier function, and reduced epithelial cell density, indicating a negative correlation between microbial diversity and DED severity (Mendez et al., 2020)

You might need to administer a larger volume to get the desired effective dose, depleting your vial faster and introducing unknown variables into your experiment

Common side effects include nausea, constipation, and difficulty meeting nutritional needs due to appetite suppression