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A molecule that is not what its label claims is not simply ineffective, it is a genuine safety concern, because you cannot know what you are actually putting into your body

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Athletic and high-performance patients usually do weekly during training peaks and monthly during off-cycles

In addition to its metabolic functions, biotin may also influence gene regulation: it can attach to specific lysine residues on histone proteins (a process known as histone biotinylation), thereby potentially affecting chromatin structure and gene expression