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"Efficacy and safety of retatrutide (TRANSCEND-T2D-1)." The Lancet, 2026

Therefore, starting retatrutide at a very low dose (1 mg or 2 mg) helps your body adjust and avoid gastrointestinal side effects

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Muscle loss can happen when: Protein intake is insufficient Physical activity, especially resistance training, is low Weight loss is rapid or extreme Studies show that people on GLP-1 drugs can lose 5-30% of their weight from muscle mass if they dont take steps to preserve it