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Research uses MT-1 to study whether the anti-inflammatory and melanogenic arms of MC1R biology can be pharmacologically dissected through downstream pathway selective interventions examining whether PKA inhibition differentially affects the two outputs and contributing to understanding of how MC1R-cAMP signalling branches to produce distinct cellular outcomes simultaneously

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Sun Q, Wang C, Yan B, Shi X, Shi Y, Qu L, Liang X (2019) Jinmaitong ameliorates diabetic peripheral neuropathy through suppressing TXNIP/NLRP3 inflammasome activation in the streptozotocin-induced diabetic rat model