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10.1016/j.tplants.2015.02.001 Trends Plant Sci

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The cardiovascular outcome trials for the new obesity pharmacotherapies will help us understand better the long-term benefits and risks with each molecule

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Safe combinations include GLP-1 receptor agonists (semaglutide, tirzepatide), growth hormone secretagogues (CJC-1295, ipamorelin), and peptides with peripheral metabolic effects (AOD-9604)

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It causes severe swelling and skin hardening, and in some cases, a skin ulcer

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The SLC7A11-GSH-GPX4 pathway is considered to be the primary negative regulatory mechanism in cells (Mao et al., 2021)

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