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Most mechanistic studies have focused on individual regulatory processes, whereas comparatively few have examined how metabolic flux, signaling pathways, and transcriptional regulation are dynamically coordinated under combined stress (Zandalinas et al., 2021)

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PTB domain (Phosphotyrosine binding domain)

That extended half-life relative to native GHRH (around 7 minutes) reflects the N-terminal hexenoyl modification's effect on DPP-IV resistance