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Rodent MSC also exhibit ameliorated osteogenic differentiation when treated with GLP-1-RA, mirroring findings in human MSC
150ml
2017;357: j2099
Most common adverse events at all doses: Nausea (3355%, dose-related) Vomiting (1335%) Decreased appetite (1528%) Constipation or diarrhea (1020%) Injection-site reaction (510%) Dose-related dysesthesia signal: The TRIUMPH-4 trial identified a dose-related dysesthesia (nerve-tingling, paresthesia) signal: This is the most-flagged trial-level safety signal for retatrutide and the reason community doses cluster at 2-4 mg/week well below where the dysesthesia signal becomes prominent
Previous studies suggested that TRPM5 activation and the subsequent increases in Na + -influx play a crucial role in GLP-1-induced increases in beta cell electrical activity [28]
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