Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors It may be the main

It may be the main paracrine factor for the proliferation of normal epithelial cells

such as intestinal

and 98% homology with mouse/dog/horse

Mature human BMP-2 has 100% amino acid sequence identity with mouse and rat BMP-2

corresponding to a specific activity of>1

Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors It may be the mainNOV is a member of the CCN family of secreted, cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilms tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased