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Raw files were converted to mzXML with msconvert 40 , extraction of LC-MS peak signals was conducted with the Centwave algorithm in XCMS, alignment of samples and filtering of artifacts with mzMatch, and additional data filtering and metabolite identification was performed in IDEOM (Supp Data Sheet 3)

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One possible explanation for the use of a lower than maximum dose at EOS could be an increased occurrence, or perhaps expectation, of gastrointestinal AEs with higher doses

However, the systemic introduction of ARA-290 in OIR mice seemed to lower the levels of pro-inflammatory cytokines like IL-1 and TNF- in the retinal tissue, hinting at its possible anti-inflammatory properties

Diabetic retinopathy: Rapid blood sugar improvements can temporarily worsen vision in patients with diabetes