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As a consequence, cells of the liver, adipose tissue, adrenal cortex, testis, and lactating mammary gland have high levels of the PPP enzymes

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This can contribute to endothelial dysfunction, making arteries less responsive and creating conditions that favor inflammation and plaque formation

FIGURE 7 4 CHAC enzymes beyond mammals Research on ChaC-like proteins has primarily focused on the mammalian homologs CHAC1 and CHAC2, with very few studies characterizing these enzymes in other organisms

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