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Cardiac magnetic resonance analyses demonstrated that exercise-related cardiac remodeling in G+P carriers mirrored physiological adaptations seen in noncarriers, without evidence of pathological hypertrophy or fibrosis

PMID: 66 PantanoIIaconoDFavalliEGScaliseGCostaLCasoFet al

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It is primarily used as the initiation dose therapy to allow gradual dose escalation and better tolerability during the early phase of treatment

In placebo groups, weight loss was much smaller or did not happen at all