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Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis
"The people who have the greatest need for these medications are precisely the people who are in lower socioeconomic strata who have either poor insurance or no insurance, and dont have the discretionary funds to be spending on medications, Krumholz, a cardiologist and professor of medicine at Yale School of Medicine, told NBC News
Metabolism of OPZ results in the production of a minor oxo analog, and the major dimethylated pyrrolopyrazine through the biological methylation of the intermediate pyrrolopyrazine thione
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Mol Cell Endocrinol 351:152166 Strobel O, Dadabaeva N, Felix K, Hackert T, Giese NA, Jesenofsky R, Werner J (2016) Isolation and culture of primary human pancreatic stellate cells that reflect the context of their tissue of origin
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