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Although GSH is involved in disulfide formation and protein folding in the ER 25 , our data showed that cystine starvation did not disrupt ER homeostasis in HepG2 cells
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These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability
165,166 The launch of Exa-cel has filled the gap in gene-editing drugs and provided considerable motivation for developing other gene-editing therapies
10.1038/nature14344 Nature 66 JiangY.MaoC.YangR.YanB.ShiY.LiuX.et al (2017)
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