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Lakhani I, Wong MV, Hung JKF et al (2021) Diagnostic and prognostic value of serum C-reactive protein in heart failure with preserved ejection fraction: a systematic review and meta-analysis

The research utilized male Sprague-Dawley rats and various in vitro and ex vivo experimental models

Parallel uninfected controls were maintained for each experiment, even when the same ECOR + AG library was being tested against different phages and the uninfected controls would be interchangeable

The idea that they shouldn't be used together comes from older laboratory research, not modern skincare formulations

the trial emulation framework helps align determination of eligibility, treatment assignment, and the beginning of follow-up, reducing important sources of biasincluding immortal time bias (which arises when treatment strategies are defined after the start of follow-up) and selection bias (which arises when follow-up starts after treatment assignment).73 We used data from the US Department of Veterans Affairs which integrates information from multiple data streams including healthcare encounters (both inpatient and outpatient), diagnostic codes, laboratory test results, vital signs, medication use, sociodemographic data, and data on use of supportive and rehabilitation services