Liraglutide (Saxenda) NICE Technology Appraisal TA664 recommends liraglutide as an option for managing overweight and obesity in adults with a BMI of 35 kg/m or more (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, within a specialist weight management service
However, its potential in aiding weight loss was soon recognized, leading to its approval for this purpose under the brand name Wegovy
Clinical trials showed joint pain occurred at similar rates in tirzepatide and placebo groups, and joint inflammation is not a known pharmacologic effect of GIP or GLP-1 receptor activation
Reported effects may include: Mild bloating or stomach discomfort Nausea Headache Skin rash Unpleasant taste (with sublingual use) Stop the medication and contact your provider promptly if you develop: Persistent abdominal pain or vomiting Wheezing or shortness of breath Severe rash or swelling Any unusual or worsening symptoms Trouble breathing Swelling of face, lips, or tongue Severe allergic reaction Chest pain, severe dizziness, or fainting Take exactly as prescribed
The infection is more common in people with weakened immune systems, for example in those with blood cancer