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The published case of semaglutide injection site nodules remains notable precisely because it was the first such report, highlighting how uncommon this presentation is

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For context, the CSF exposure of monoclonal antibodies used in Alzheimers disease typically ranges from 0.1% to 0.3% of plasma concentrations, whereas small-molecule CNS drugs often exceed 5%, placing semaglutide within a low but pharmacologically plausible exposure range

Here's what makes the difference: looking for patterns, not just data points