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Studies using PET imaging to quantify neuroinflammation in the brain have revealed significant differences between healthy controls and ALS patients, but data are preliminary and sample sizes have been small, leading authors to conclude that caution should be taken against over-interpretation of findings ( via PET imaging may eventually be a tool that could be used to monitor disease progression, it could not be used as a diagnostic measure

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A significant rate of severe jaundice causing kernicterus still plagues much of the world population especially in lower income economies

Mahroo et al., 2021