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Therefore, we cannot directly conclude that the observed improvements in endocrine-metabolic profiles and oxidative stress in PCOS mouse ovaries following NAC intervention lead to enhanced fertility

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Pain outcomes (WOMAC pain score): Additional findings: Systolic blood pressure reduced by 14 mmHg at 12 mg Improved non-HDL cholesterol, triglycerides, and hsCRP (a marker of inflammation) New safety signal -- dysesthesia: Dysesthesia (abnormal sensations such as burning, tingling, or numbness) emerged as a new adverse event in this trial: 8.8% at 9 mg 20.9% at 12 mg 0.7% at placebo TRIUMPH-5 -- Head-to-Head vs Tirzepatide TRIUMPH-5 is a Phase 3 head-to-head efficacy trial comparing retatrutide to tirzepatide in adults with obesity

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placebo in patients who were overweight or obese and showed sustained, clinically relevant weight loss and improvement in lipid parameters