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Neurotransmitter synthesis , including serotonin and dopamine

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Plasma SPARC levels positively correlate with lumbar spine BMD, and 12 months of recombinant human parathyroid hormone (134) treatment in osteoporotic patients increases the circulating SPARC level, which is associated with changes in lumbar BMD at L2-L4 [24]

However, the peptide characteristics that enable absorption through the gastric mucosa, including its stability in acidic environments and resistance to enzymatic degradation, suggest it should maintain activity when absorbed through nasal mucosa as well

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