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doi: 10.1136/ard.2006.062554 150 XuMHongRZhangXZouHZhangYHouZet al

It is downregulated in gastric and colorectal cancers but upregulated in lung adenocarcinoma and breast tumors compared to normal tissue ( In gastric and colorectal cancer, high CHAC2 expression leads to reduced glutathione, elevated intracellular Ca 2+ and increased ROS, resulting in inhibited tumor growth, proliferation and migration

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