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The hypothalamicpituitary axis (HPA) coordinates the release of GHRH, which stimulates pituitary somatotroph cells to synthesize and release GH, alongside somatostatin, which exerts inhibitory control over GH secretion

However, this therapy is not appropriate for everyone

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This finding was later confirmed in a study from 1995, which used high pressure liquid chromatography in combination with radioimmunoassay making it possible to specifically analyze intact GLP-1 and its metabolites