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It was the IGF-1 cascade genes that became the first discovered "aging genes" that is, genes whose damage led to an increase in life expectancy
Such a direct GLP-1 mechanism is supported by studies using native GLP-1 and exenatide in healthy people and patients with T2DM showing that the acute increase of HR was not preceded by a decrease in blood pressure, was not associated with changes in plasma levels of adrenaline or noradrenaline, and was independent of GLP-1 glucoregulatory effects [11, 34, 35]
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Currently, subcutaneous delivery via needle-based syringes or pens is the common route of administration for GLP-1 receptor agonists
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