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What is reasonable to monitor Weight and waist circumference Trial endpoints

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The manifestations of mitochondrial dysfunction in AD mainly include increased oxidative stress and ROS production, 152,153 mitochondrial DNA damage, 154 mitochondrial respiratory injury, 155 and calcium abnormalities

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If the patient is losing weight faster than 1% of body weight per week, that would be another indicator that the patient is at risk for developing micronutrient deficiencies