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While the heart rate increase associated with tirzepatide is generally modest and well-tolerated, patients with pre-existing arrhythmias or those taking beta blockers for rate control may require closer monitoring
These studies suggest that GLP-1 may mediate cholesterol outflow in hepatocytes through the LXR-ABCA1 pathway, consequently avoiding large amounts of cholesterol accumulation in cells
The panel figure shows cumulative incidence estimated using the Kaplan-Meier method of hospitalization for heart failure ( A ), major adverse liver events ( B ), and body weight decline of 5% ( C ), 10% ( D ) and 15% ( E ) among patients with type 1 diabetes initiating GLP-1RA (blue) and not initiating GLP-1RA (red)
Louis Health Care System, told The Associated Press
