once-weekly semaglutide in adults with overweight or obesity Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has well-established weight-loss benefits. Cagrilintide, a long-acting analogue of the satiety hormone amylin, has shown promise for weight loss early trials. The potential benefit GLP-1 agonists for weight loss:
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