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This signal is crucial for maintaining and improving brain function, especially in conditions where neuronal loss or damage is prevalent

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doi:10.1016/j.smrv.2024.101930

TLR4 belong to the family of patter recognition receptors (PRRs) and is expressed in several immune cells, such as monocytes, macrophages, and Kupffer cells, but also endothelial cells, adipocytes, and hepatocytes

Curcumin, the active compound in turmeric, increases BDNF in the hippocampus and has shown synergistic effects when combined with exercise