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Clinical PK 1999 Phase I pharmacokinetics in healthy human volunteers (IV) Gobburu, Agers, Jusko, and Ynddal reported dose-proportional pharmacokinetics across five IV dose levels (4.21140.45 nmol/kg) in eight healthy male volunteers per level

Long-Term Concerns and the Need for Research While most reported side effects are mild and transient, its important to acknowledge the potential long-term concerns raised in research

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Clinically, low albumin (e.g., in liver disease or nephrotic syndrome) can lead to edema due to decreased oncotic pressure

Much of the current evidence comes from laboratory and animal studies, which are encouraging but are not a substitute for large, long-term human clinical trials