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TDP-43 pathology was originally defined with the accumulation of proteins that include phosphorylated TDP-43 (pTDP-43) in the cytoplasm of neurons that undergo degeneration 10 , and this pathology was broadly observed in a wide spectrum of ALS cases 44
Roy Cooper
Without proper monitoring, early warning signs go unnoticed and long-term outcomes suffer
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Consequently, it appears that both fALS and sALS astrocytes secrete factors that are toxic to motor neurons, or alternatively do not provide factors needed for motor neuron survival, resulting in cell death
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