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Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2 expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

Currently, however, its exact roles in disease development and prevention remain unclear

This reaction simultaneously converts GSH into its oxidized form, glutathione disulfide (GSSG) [37]

A colony formation assay further confirmed a significant reduction in colony number, area, and size compared with the control and single-agent treatments (Fig