Folic Acid Methylfolate (L-5-methylfolate, sold as Metafolin and Quatrefolic) is a form of folate promoted for use by people with common genetic mutations that affect the MTHFR enzyme
298,311 Over-activation of glutamate-sensitive receptors in the brain can further degrade blood-brain barrier function and trigger excitotoxicity, neuroinflammation, increased oxidative stress, protein aggregation, mitochondrial dysfunction, and nerve cell death, and is considered a possible contributor to cognitive disorders, depression, reduced neuroplasticity, and neurodegenerative diseases like Alzheimer disease, Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Huntington disease
The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida
Follow with sunscreen during the daytime for best results
While Mounjaro has shown promising results, it is still a newer product with relatively limited market penetration compared to the more established options from Novo
