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Across premenopausal, perimenopausal, and postmenopausal women, tirzepatide produced similar reductions in body weight, waist circumference, and central adiposity
Average plasma glucose levels before breakfast, lunch, and dinner, and the decreased amplitude of glycemic excursions were calculated
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Long, R., Adrian, T
Additionally, obesity and IR both contribute to -cell dysfunction and apoptosis, mechanistically explained by glucotoxicity and increased immunogenicity (the accelerator hypothesis) or by -cell exhaustion due to increased metabolic demand (the overload hypothesis) [23]
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