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Methods This is an open-label, multicenter, randomized, prospective, parallel-group comparison study

Occupational hazards like stress, sleep disruption, and shift work play a key role

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Similarly, if kidney function declines during treatmentwhether due to dehydration, illness, or age-related changesmetformin may need to be stopped because the kidneys cannot safely clear the medication

Acute AOD9604 exposure, however, still increased energy expenditure and fat oxidation in the knockout animals