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However, recent insights suggest that the gut and brain GLP-1 systems operate largely independently with mRNA transcripts for proglucagon (GCG), the precursor peptide for GLP-1, being abundant in the brainstem, particularly within the nucleus tractus solitarius (NTS

Cohen thinks its probably a product of bacteria that live in the gut.) Studies have touted a staggering variety of benefits in cells and animals

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Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes