retatrutide vs semaglutide reddit Promises Big Weight Loss, but Safety Remains a Question Semaglutide vs tirzepatide vs retatrutide:

Semaglutide has been shown to be effective for weight loss in people with obesity

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Future studies are needed to determine if GLP-1R pharmacotherapy has similar effects on VTA GABA neurons during cue-induced and/or stress-induced reinstatement

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The licensing of oral semaglutide provided a step forward in type 2 diabetes management for this group, and the publication of the SOUL study in 2025 reassured us that oral semaglutide could also offer cardiovascular benefit in those at highest risk