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These results demonstrated that 12-ursene 2-diketone inhibits the expression of pro-inflammatory cytokines and mediators via inhibition of phosphorylation of the mitogen-activated protein kinases (MAPK), Jun N-terminal kinase (JNK) and p38MAPK, while no inhibition was seen in ERK phosphorylation in LPS-stimulated PBMC

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The extensive SURPASS clinical trials, encompassing eight completed studies, have evaluated tirzepatide as both monotherapy and in combination with other treatments (4)

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