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Further studies will be required to assess whether COPD-associated differences in ECM remodeling by distal fibroblasts in vitro is associated with the regional disease severity in the tissue from which the fibroblasts are derived

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If there has been no benefit after 3 months of treatment, then the hydroquinone should be stopped

K1 cells were again treated with various concentrations of RSL3 (0.0053 M), and Western blot analysis was performed

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress